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|Title:||The effect of atenolol, a beta1-adrenergic antagonist, on nocturnal plasma melatonin secretion: evidence for a dose-response relationship in humans.|
|Authors:||Nathan, P J;Maguire, K P;Burrows, Graham D;Norman, Trevor R|
|Affiliation:||University of Melbourne, Department of Psychiatry, Austin and Repatriation Medical Centre, Heidelberg, Germany.|
|Citation:||Journal of Pineal Research; 23(3): 131-5|
|Abstract:||Pineal beta1-adrenergic receptors are involved in the regulation of melatonin secretion. The involvement of beta1-adrenergic receptors has been demonstrated by the ability of acute administration of beta-antagonists to suppress the nocturnal rise of circulating melatonin and its urinary metabolite 6-sulphatoxymelatonin (aMT6s). The present study was undertaken to examine the relationship between increasing doses of atenolol and nocturnal plasma melatonin concentrations. Six healthy subjects participated in the study for a period of 5 weeks. Subjects were administered placebo, 12.5, 25, 37.5, and 50 mg doses of atenolol in a randomized single blind design. Each dose was separated by a 1 week washout period. Blood samples were collected at regular intervals from 19.00 hr to 06.00 hr. Repeated measures analysis of variance showed a dose-dependent decrease in plasma melatonin concentrations (P<0.01). A Student Newman-Keuls post hoc test indicated significant differences between placebo and all doses of atenolol (P<0.05). The results demonstrate a dose-dependent relationship between beta1-receptor blockade and suppression of nocturnal plasma melatonin in humans.|
|Internal ID Number:||9406983|
Adrenergic beta-Antagonists.administration & dosage
Atenolol.administration & dosage
Dose-Response Relationship, Drug
Pineal Gland.drug effects
Receptors, Adrenergic, beta-1.drug effects
|Appears in Collections:||Journal articles|
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