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https://ahro.austin.org.au/austinjspui/handle/1/13548
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hardy, Kenneth John | en |
dc.contributor.author | Tancheroen, S | en |
dc.contributor.author | Shulkes, Arthur | en |
dc.date.accessioned | 2015-05-16T03:25:30Z | |
dc.date.available | 2015-05-16T03:25:30Z | |
dc.date.issued | 1995-09-01 | en |
dc.identifier.citation | Liver Transplantation and Surgery : Official Publication of the American Association For the Study of Liver Diseases and the International Liver Transplantation Society ; 1(5): 302-10 | en |
dc.identifier.govdoc | 9346587 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13548 | en |
dc.description.abstract | The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin analogue) or nifedipine (a calcium antagonist), know protectants of the whole liver, would ameliorate the ischemia-reperfusion injury (IRI) of resected liver associated with vascular occlusion. Male Wistar rats were allocated to 5 groups (n = 20 each group): sham-operated, liver resection only, liver resection plus pretreatment with 0.1 mg/kg misoprostol, 10 mg/kg, or 2 mg/kg nifedipine during the 3 days before IRI with liver resection. Fifteen percent of the liver was made ischemic by 30-minute continuous vascular occlusion, and the remaining 85% nonischemic liver was resected. The model was designed to have survival of the rats so that liver function could be studied over 3 weeks. Seventeen of 20 control resection rats survived indicating a suitable model for study. The bilirubin level was reduced by 25% on postoperative days 3 through 23 with misoprostol. The serum alanine aminotransferase (ALT) peak was significantly lower on day 1 with misoprostol and high-dose nifedipine (both reduced to half the control resection value). There was a modest but significant reduction of serum alkaline phosphatase (SAP) for low-dose nifedipine on days 1, 2, and 23. Prothrombin had a lower peak and lower values on days 1 through 4 with misoprostol. Liver histological changes were minor, being cytoplasmic vacuolization only, and was slightly more marked in the nifedipine groups. Preoperative misoprostol 0.1 mg/kg and nifedipine 10 mg/kg each ameliorate the IRI associated with liver resection, as measured by liver function tests. Different aspects of liver function were altered by the different agents. These results justify initiating a trial for human liver resections. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Calcium Channel Blockers.therapeutic use | en |
dc.subject.other | Disease Models, Animal | en |
dc.subject.other | Hepatectomy | en |
dc.subject.other | Liver.blood supply.drug effects.surgery | en |
dc.subject.other | Liver Diseases.etiology.physiopathology.prevention & control | en |
dc.subject.other | Liver Function Tests | en |
dc.subject.other | Male | en |
dc.subject.other | Misoprostol.therapeutic use | en |
dc.subject.other | Nifedipine.therapeutic use | en |
dc.subject.other | Organ Size | en |
dc.subject.other | Oxytocics.therapeutic use | en |
dc.subject.other | Random Allocation | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Wistar | en |
dc.subject.other | Reperfusion Injury.etiology.physiopathology.prevention & control | en |
dc.title | Hepatic ischemia-reperfusion injury modification during liver surgery in rats: pretreatment with nifedipine or misoprostol. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | en |
dc.identifier.affiliation | Department of Surgery, Austin Hospital, Melbourne, Australia | en |
dc.description.pages | 302-10 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/9346587 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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