Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13545
Title: Supramedullary modulation of sympathetic vasomotor function.
Authors: Verberne, Anthony J M;Lam, W;Owens, N C;Sartor, Daniela M
Affiliation: University of Melbourne, Department of Medicine, Victoria, Australia. tonyv@austin.unimelb.edu.au
Issue Date: 10-Sep-1997
Citation: Clinical and Experimental Pharmacology & Physiology; 24(9-10): 748-54
Abstract: 1. Supramedullary structures including the ventral medial prefrontal cortex (MPFC) and the midbrain cuneiform nucleus (CnF) project directly and indirectly to premotor sympatho-excitatory neurons of the rostral ventrolateral medulla (RVLM) that are critically involved in the generation of sympathetic vasomotor tone. 2. Electrophysiological studies have demonstrated that activation of depressor sites within the MPFC is associated with splanchnic sympathetic vasomotor inhibition and inhibition of the activity of RVLM sympathoexcitatory neurons. 3. Antidromic mapping and anatomical studies support the notion that a relay in the nucleus tractus solitarius is involved in the cardiovascular response to MPFC stimulation. 4. The midbrain CnF, which lies adjacent to the midbrain periaqueductal grey, is a sympathoexcitatory region of the midbrain reticular formation. Sympathoexcitatory responses evoked from the CnF are associated with short-latency excitation of RVLM neurons. 5. Cuneiform nucleus stimulation induces the expression of mRNA for the immediate early genes c-fos and NGFI-A in mid-brain, pontine and hypothalamic structures. 6. The MPFC and CnF are supramedullary structures with opposing modulatory influences on sympathetic vasomotor drive, whose roles in cardiovascular control mechanisms warrant further investigation.
Internal ID Number: 9315383
URI: http://ahro.austin.org.au/austinjspui/handle/1/13545
URL: http://www.ncbi.nlm.nih.gov/pubmed/9315383
Type: Journal Article
Subjects: Animals
Autonomic Pathways.physiology
Humans
Medulla Oblongata.physiology
Muscle, Smooth, Vascular.innervation.physiology
Neurotransmitter Agents.physiology
Sympathetic Nervous System.physiology
Appears in Collections:Journal articles

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