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|Title:||Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat.|
|Authors:||Jenkins, T A;Chai, Syn Y;Mendelsohn, Frederick AO|
|Affiliation:||University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia|
|Citation:||Clinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 645-58|
|Abstract:||We have previously demonstrated that angiotensin II stimulates the release of dopamine from the normotensive rat striatum via the AT1 receptor. In this study, the effect of angiotensin II-stimulated striatal dopamine release in the spontaneous hypertensive rat was compared to normotensive controls. In the spontaneous hypertensive rat, angiotensin II stimulated dopamine release to 169 +/- 13% (P < 0.05) in the experimental period, with levels remaining high in the recovery phase, 158 +/- 16% (P < 0.05). This effect was not significantly different from the response in normotensive controls, in which angiotensin II stimulated dopamine release to 149 +/- 18% (P < 0.05) in the experimental period, with the effect also persisting through the recovery period, 244 +/- 62% (P < 0.05). Thus, despite reports of increased activity of the brain angiotensin II and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system.|
|Internal ID Number:||9247745|
Corpus Striatum.drug effects.secretion
Rats, Inbred SHR
|Appears in Collections:||Journal articles|
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