Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13537
Title: Effect of angiotensin II on striatal dopamine release in the spontaneous hypertensive rat.
Authors: Jenkins, T A;Chai, Syn Y;Mendelsohn, Frederick AO
Affiliation: University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Issue Date: 8-Jul-1997
Citation: Clinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 645-58
Abstract: We have previously demonstrated that angiotensin II stimulates the release of dopamine from the normotensive rat striatum via the AT1 receptor. In this study, the effect of angiotensin II-stimulated striatal dopamine release in the spontaneous hypertensive rat was compared to normotensive controls. In the spontaneous hypertensive rat, angiotensin II stimulated dopamine release to 169 +/- 13% (P < 0.05) in the experimental period, with levels remaining high in the recovery phase, 158 +/- 16% (P < 0.05). This effect was not significantly different from the response in normotensive controls, in which angiotensin II stimulated dopamine release to 149 +/- 18% (P < 0.05) in the experimental period, with the effect also persisting through the recovery period, 244 +/- 62% (P < 0.05). Thus, despite reports of increased activity of the brain angiotensin II and dopamine systems in the spontaneous hypertensive rat, there is no evidence of abnormal regulation of the striatonigral dopamine system.
Internal ID Number: 9247745
URI: http://ahro.austin.org.au/austinjspui/handle/1/13537
URL: http://www.ncbi.nlm.nih.gov/pubmed/9247745
Type: Journal Article
Subjects: Angiotensin II.pharmacology
Animals
Corpus Striatum.drug effects.secretion
Dopamine.secretion
Hypertension.physiopathology
Microdialysis
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Species Specificity
Appears in Collections:Journal articles

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