Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13511
Title: Aggressive behaviour and platelet 3H-paroxetine binding in schizophrenia.
Authors: Maguire, K;Cheung, P;Crowley, K;Norman, Trevor R;Schweitzer, I;Burrows, Graham D
Affiliation: Department of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Issue Date: 17-Jan-1997
Citation: Schizophrenia Research; 23(1): 61-7
Abstract: Forty schizophrenic patients were included in a study of the relationship between serotonin function as measured by 3H-paroxetine binding to platelet membranes and aggressive behaviour. Patients classified as either aggressive or non-aggressive were paired by age, sex and duration of illness. 3H-Paroxetine binding variations were avoided by taking samples for each pair between 09:00 and 11:00 h, within 4 days of each other, and by assaying pair of samples together. The mean Kd for the aggressive group was 0.193 +/- 0.126 nM and the mean Kd for the non-aggressive group was 0.176 +/- 0.164 nM. The mean Bmax for the aggressive group was 1451 +/- 386 fmol/mg protein while the mean for the non-aggressive group was 1549 +/- 375 fmol/mg protein. There was no significant difference between the groups for either parameter, Kd or Bmax. There were no significant correlations between psychopathology rating including positive and negative symptoms, depression, suicidal thoughts, impulse control, as well as both past and present history of aggression, hostility and irritability traits, psychopathic deviance and either Bmax and Kd. This study finds no relationship between aggressive behaviour and peripheral serotonin function as measured by 3H-paroxetine binding to platelet membranes.
Internal ID Number: 9050129
URI: http://ahro.austin.org.au/austinjspui/handle/1/13511
DOI: 10.1016/S0920-9964(96)00092-8
URL: http://www.ncbi.nlm.nih.gov/pubmed/9050129
Type: Journal Article
Subjects: Adult
Aggression.physiology.psychology
Blood Platelets.metabolism
Carrier Proteins.metabolism
Female
Humans
Male
Middle Aged
Paroxetine.pharmacokinetics
Psychiatric Status Rating Scales
Receptors, Drug.metabolism
Receptors, Serotonin.physiology
Schizophrenia.physiopathology
Schizophrenic Psychology
Serotonin.physiology
Serotonin Uptake Inhibitors.pharmacokinetics
Appears in Collections:Journal articles

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