Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13510
Title: Angiotensin-converting enzyme modulates dopamine turnover in the striatum.
Authors: Jenkins, T A;Mendelsohn, Frederick AO;Chai, Syn Y
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Issue Date: 1-Mar-1997
Citation: Journal of Neurochemistry; 68(3): 1304-11
Abstract: The effect of chronic inhibition of the angiotensin-converting enzyme on dopamine content and release in the striatum was investigated using in vivo microdialysis in awake, freely moving rats. Rats were treated for 1 week with the angiotensin-converting enzyme inhibitor perindopril (1 mg/kg) via the drinking water, whereas the controls were given water alone. One week after perindopril treatment, striatal dopamine dialysate levels in the treated group were markedly elevated compared with control values: control, 233 +/- 43 pg/ml; perindopril, 635 +/- 53 pg/ml (p < 0.001). These results were confirmed by a complementary study in which dopamine content was measured in striatal extracts (3.5 +/- 0.4 micrograms of dopamine/g of tissue for controls compared with 9.2 +/- 2.4 micrograms of dopamine/g of tissue for the treated group; p < 0.05). In the rats that were dialyzed, angiotensin-converting enzyme levels in the striatum were decreased by 50% after perindopril treatment. Levels of dopamine D1 and D2 receptors and of preprotachykinin and tyrosine hydroxylase mRNAs were unchanged after angiotensin-converting enzyme inhibition. A small, but significant, increase was detected in striatal preproenkephalin mRNA levels in the angiotensin-converting enzyme inhibitor-treated group. These results indicate that peripherally administered angiotensin-converting enzyme inhibitors penetrate the blood-brain barrier when given chronically and modulate extracellular dopamine and striatal neuropeptide levels.
Internal ID Number: 9048778
URI: http://ahro.austin.org.au/austinjspui/handle/1/13510
URL: http://www.ncbi.nlm.nih.gov/pubmed/9048778
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.pharmacology
Animals
Autoradiography
Corpus Striatum.metabolism
Dopamine.metabolism
In Situ Hybridization
Male
Neuropeptides.genetics
Peptidyl-Dipeptidase A.genetics.physiology
RNA, Messenger.metabolism
Rats
Rats, Sprague-Dawley
Time Factors
Appears in Collections:Journal articles

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