Please use this identifier to cite or link to this item:
|Title:||Polyarteritis nodosa and antiglomerular basement membrane disease without antineutrophil cytoplasm antibodies.|
|Authors:||Kirkland, G S;Savige, Judy A;Sinclair, R A;Hennessy, O F|
|Affiliation:||Department of Medicine, Austin Hospital, Heidelberg, Vic., Australia.|
|Citation:||American Journal of Nephrology; 16(5): 442-5|
|Abstract:||Antiglomerular basement membrane (GBM) antibodies have been described previously in patients with microscopic polyarteritis but not in patients with polyarteritis nodosa alone. Where anti-GBM antibodies occur in microscopic polyarteritis, antineutrophil cytoplasm antibodies (ANCA) are usually present. We describe here a patient with polyarteritis nodosa and anti-GBM antibodies in whom ANCA could not be demonstrated. A 72-year-old woman presented with abdominal pain, diarrhoea and acute renal failure. A renal biopsy showed crescentic glomerulonephritis and linear immunofluorescence of the GBM consistent with anti-GBM disease. In addition, there was evidence of large-and medium-sized vessel vasculitis on abdominal angiography, performed because of persisting abdominal pain. There was no small vessel vasculitis on histological examination of the renal biopsy and ANCA could not be demonstrated by indirect immunofluorescence or ELISA.|
|Internal ID Number:||8886183|
|Subjects:||Acute Kidney Injury.etiology.immunology.pathology|
Antibodies, Antineutrophil Cytoplasmic.immunology
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.