Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13473
Title: HIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes.
Authors: Dawson, M J;Trapani, Joseph A
Affiliation: Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Australia.
Issue Date: 1-Sep-1996
Citation: Journal of Leukocyte Biology; 60(3): 310-6
Abstract: In recent years a novel family of interferon (IFN)-inducible nuclear proteins has been identified in both mouse and humans and implicated in the control of myeloid differentiation. Recent evidence suggests that this role may be mediated by an effect on cell cycle regulation through interaction with known transcriptional regulators. Our laboratory first identified a nuclear protein designated IFI 16, which is strongly inducible with IFN-alpha and -gamma in myeloid cells. IFI 16 shares homology with at least six IFN-inducible mouse genes, designated the Gene 200 cluster, and also has close similarity with the human myeloid cell nuclear differentiation antigen, whose expression has also been associated with later stages of normal myelopoiesis and some myeloid malignancies. The structural hallmark of each protein in this family of hemopoietic IFN-inducible nuclear proteins is a 200-amino acid motif (hence HIN-200), present singly or as a tandem repeat. The restricted expression of these proteins, their ability to bind to nucleic acid, and their expression in response to a variety of stimuli eliciting myeloid differentiation strongly suggest that they play a role in hemopoietic maturation.
Internal ID Number: 8830786
URI: http://ahro.austin.org.au/austinjspui/handle/1/13473
URL: http://www.ncbi.nlm.nih.gov/pubmed/8830786
Type: Journal Article
Subjects: Animals
Base Sequence
Humans
Interferons.physiology
Leukocytes.metabolism
Mice
Molecular Sequence Data
Nuclear Proteins.biosynthesis
Sequence Homology, Nucleic Acid
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.