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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baldwin, Graham S | en |
dc.contributor.author | Abbott, F S | en |
dc.contributor.author | Nau, H | en |
dc.date.accessioned | 2015-05-16T03:18:59Z | |
dc.date.available | 2015-05-16T03:18:59Z | |
dc.date.issued | 1996-04-08 | en |
dc.identifier.citation | Febs Letters; 384(1): 58-60 | en |
dc.identifier.govdoc | 8797803 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13462 | en |
dc.description.abstract | The anti-convulsant drug valproate causes hepatic failure in a small percentage of patients. We now report that the valproate metabolite 2,4-dien-valproate binds (IC50 = 42 microM) to the alpha-subunit of the trifunctional protein responsible for the second and third steps in the mitochondrial beta-oxidation of fatty acids. Binding of valproate itself, or of the metabolites 2-envalproate, 4-en-valproate or 3-hydroxy-4-en-valproate, is considerably weaker. We conclude that valproate-induced hepatotoxicity may be due in part to the reversible binding of the valproate metabolite 2,4-dien-valproate or its CoA ester to the alpha-subunit of the trifunctional protein with consequent inhibition of fatty acid oxidation. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Anticonvulsants.metabolism.toxicity | en |
dc.subject.other | Fatty Acids.metabolism | en |
dc.subject.other | Gastric Mucosa.metabolism | en |
dc.subject.other | Kinetics | en |
dc.subject.other | Liver.drug effects.pathology | en |
dc.subject.other | Macromolecular Substances | en |
dc.subject.other | Mitochondrial Trifunctional Protein | en |
dc.subject.other | Multienzyme Complexes.isolation & purification.metabolism | en |
dc.subject.other | Oxidation-Reduction | en |
dc.subject.other | Protein Binding | en |
dc.subject.other | Swine | en |
dc.subject.other | Valproic Acid.analogs & derivatives.metabolism.toxicity | en |
dc.title | Binding of a valproate metabolite to the trifunctional protein of fatty acid oxidation. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | FEBS letters | en |
dc.identifier.affiliation | Department of Surgery, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 58-60 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/8797803 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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