Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13419
Title: Intrastriatal angiotensin II induces turning behaviour in 6-hydroxydopamine lesioned rats.
Authors: Jenkins, T A;Chai, Syn Y;Howells, David William;Mendelsohn, Frederick AO
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Issue Date: 11-Sep-1995
Citation: Brain Research; 691(1-2): 213-6
Abstract: In rats with unilateral 6-hydroxydopamine lesions in the nigrostriatal pathway, injection of angiotensin II (2 nmol) into the unlesioned striatum elicited dose-related tight rotations ipsilateral to the lesion. This rotation was suppressed by coadministration of the angiotensin AT1 receptor antagonist, losartan (2 nmol), which had no significant effect when injected alone. Preadministration of the dopamine antagonist, haloperidol (2 mg/kg i.p.) completely blocked angiotensin II-induced turning at doses of 0.3-3 nmol, and partially at 10 nmol. These results further confirm the hypothesis that Ang II is intrinsically involved in modulating dopamine release in the striatum, an effect which is mediated predominantly by AT1 receptors.
Internal ID Number: 8590055
URI: http://ahro.austin.org.au/austinjspui/handle/1/13419
URL: http://www.ncbi.nlm.nih.gov/pubmed/8590055
Type: Journal Article
Subjects: Angiotensin II.antagonists & inhibitors.pharmacology
Animals
Biphenyl Compounds.pharmacology
Corpus Striatum.drug effects
Dopamine.physiology
Functional Laterality.physiology
Haloperidol.pharmacology
Imidazoles.pharmacology
Losartan
Male
Motor Activity.drug effects
Oxidopamine
Rats
Rats, Sprague-Dawley
Rotation
Substantia Nigra.drug effects
Tetrazoles.pharmacology
Appears in Collections:Journal articles

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