Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13406
Title: Potent inhibitory effect of SR 49059, an orally active non-peptide vasopressin VIa receptor antagonist, on human arterial coronary bypass graft.
Authors: Liu, J J;Chen, J R;Buxton, Brian F;Johnston, Colin I;Burrell, Louise M
Affiliation: Department of Cardiac Surgery, University of Melbourne, Austin, Australia.
Issue Date: 1-Nov-1995
Citation: Clinical Science (london, England : 1979); 89(5): 481-5
Abstract: 1. The effect of vasopressin receptor antagonists varies between analogues (peptide, non-peptide) and across species. In this study the effect of the novel non-peptide vasopressin V1a receptor antagonist SR 49059 on human internal mammary arteries was investigated. 2. SR 49059 produced a potent, concentration-dependent, inhibitory effect on vasopressin-induced contraction of human coronary bypass graft internal mammary arteries. Both SR 49059 (1 mumol/l) and a peptide selective V1a antagonist ([d(CH2)5sarcosine7]arginine vasopressin) (1 mumol/l) abolished vasopressin-induced contraction. The non-peptide V1a receptor antagonist OPC-21268 (1 mumol/l) had no effect on vasopressin-induced contraction. 3. The effect of SR 49059 was specific to vascular vasopressin receptors as noradrenaline-induced contraction was not influenced by SR 49059. 4. The results of this study in vitro indicate that the non-peptide SR 49059 is a potent, specific vasopressin V1a receptor antagonist in the human internal mammary artery and suggest that it may be a useful tool for studying the pathophysiological role of vasopressin in man.
Internal ID Number: 8549062
URI: http://ahro.austin.org.au/austinjspui/handle/1/13406
URL: http://www.ncbi.nlm.nih.gov/pubmed/8549062
Type: Journal Article
Subjects: Antidiuretic Hormone Receptor Antagonists
Arginine Vasopressin.antagonists & inhibitors
Arteries.drug effects
Hormone Antagonists.pharmacology
Humans
Indoles.pharmacology
Mammary Arteries
Muscle Contraction.drug effects
Pyrrolidines.pharmacology
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.