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|Title:||Localization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography.|
|Authors:||Burazin, T C;Gundlach, Andrew L|
|Affiliation:||University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Vic, Australia.|
|Citation:||Neuroreport; 6(14): 1842-4|
|Abstract:||Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confirms the heterogeneous distribution of the NOS enzyme. [3H]L-NOARG binding was enriched in discrete neuronal populations and the distribution observed was identical to that previously described for NOS using immunohistochemistry, in situ hybridization and NADPH-diaphorase staining. [3H]L-NOARG autoradiography should be a useful method for the further characterization and quantification of NOS in brain and other tissues.|
|Internal ID Number:||8547580|
Arginine.analogs & derivatives.metabolism
Nitric Oxide Synthase.analysis.antagonists & inhibitors
|Appears in Collections:||Journal articles|
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