Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13397
Title: Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney.
Authors: King, P R;Suzuki, Satoshi;Louis, William J;Gundlach, Andrew L
Affiliation: University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Vic., Australia.
Issue Date: 15-Aug-1995
Citation: European Journal of Pharmacology; 281(3): 341-6
Abstract: Comparative autoradiography revealed that the imidazolines [3H]p-aminoclonidine and [3H]idazoxan labelled high densities of alpha 2A-adrenoceptor sites in the inner medulla and inner stripe of the outer medulla of rat kidney. In contrast, the oxazoline [3H]rilmenidine labelled a high density of non-adrenergic sites in the cortex and outer stripe of the outer medulla, a lower density in the inner stripe and inner medulla and a low density of alpha 2A-adrenoceptor sites in inner medulla. The existence of novel, non-adrenergic oxazoline sites of potential functional importance in rat kidney has important implications for the classification of imidazoline receptors.
Internal ID Number: 8521919
URI: http://ahro.austin.org.au/austinjspui/handle/1/13397
URL: http://www.ncbi.nlm.nih.gov/pubmed/8521919
Type: Journal Article
Subjects: Adrenergic alpha-Antagonists.pharmacology
Animals
Autoradiography
Binding Sites
Dioxanes.pharmacology
Idazoxan
Imidazoles.pharmacology
Kidney.drug effects
Male
Oxazoles.pharmacology
Radioligand Assay
Rats
Rats, Inbred WKY
Appears in Collections:Journal articles

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