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Title: Pharmacokinetic aspects of antidepressant treatment in the elderly.
Authors: Norman, Trevor R
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-May-1993
Citation: Progress in Neuro-psychopharmacology & Biological Psychiatry; 17(3): 329-44
Abstract: 1. Physiological and metabolic changes with ageing may affect the pharmacokinetics of antidepressant drugs. 2. Pharmacokinetic parameters following single doses of antidepressants in the elderly tend to be altered compared with younger subjects. 3. Elimination half-life tends to be prolonged for most antidepressant drugs in the elderly due to decreased clearance and increased volume of distribution. 4. Steady-state plasma concentrations tend to be increased in elderly patients. 5. Inter-individual differences usually account for the majority of the variance in kinetic parameters rather than an effect of ageing per se. 6. The increased propensity for side effects in the elderly is probably due to pharmacodynamic rather than pharmacokinetic alterations with age.
Internal ID Number: 8475316
Type: Journal Article
Subjects: Aged
Antidepressive Agents.pharmacokinetics.therapeutic use
Depressive Disorder.drug therapy.metabolism
Appears in Collections:Journal articles

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