Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13374
Title: Distribution of angiotensin II receptor subtypes in the rabbit brain.
Authors: Aldred, G P;Chai, Syn Y;Song, K;Zhuo, J;MacGregor, Duncan;Mendelsohn, Frederick AO
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia.
Issue Date: 19-Mar-1993
Citation: Regulatory Peptides; 44(2): 119-30
Abstract: We have determined the distribution of angiotensin II receptor subtypes in rabbit brain using in vitro autoradiography. AT1 receptors were found in very high concentrations in the forebrain circumventricular organs--the subfornical organ, organum vasculosum of the lamina terminalis, and the median eminence as observed in other mammals. However, there was very little labeling in the area postrema. In the paraventricular nucleus, median preoptic nucleus, supraoptic nucleus there were high levels of predominantly AT1 receptors. High densities of AT1 receptors were also found in the nucleus of the solitary tract and the rostral and caudal ventrolateral medulla. All of these regions have putative roles in the regulation of blood pressure and fluid and electrolyte balance. In the rabbit brain there is less AT2 receptor binding than the rat, with most AT2 binding found in the molecular layer of the cerebellum and in the septohypothalamic nucleus. In the subthalamic nucleus, the mediodorsal and ventroposterior nuclei of the thalamus, locus coeruleus and inferior olivary nuclei, areas containing mostly AT2 receptors in the rat, no binding was detected in the rabbit except in the locus coeruleus which contains moderate levels of AT1 receptors. Taken in conjunction with our previous results in the rat and human brains, these results reveal that AT1 receptors predominate in rostral forebrain, hypothalamus and autonomic control centers of the medulla oblongata in all three species. However, the distribution and density of AT2 bearing sites in regions such as the septum, thalamus subthalamic nuclei, locus coeruleus, cerebellum and inferior olivary nuclei show marked species differences.
Internal ID Number: 8469767
URI: http://ahro.austin.org.au/austinjspui/handle/1/13374
URL: http://www.ncbi.nlm.nih.gov/pubmed/8469767
Type: Journal Article
Subjects: Amygdala.chemistry
Animals
Autoradiography
Brain Chemistry
Cerebellum.chemistry
Hippocampus.chemistry
Hypothalamus.chemistry
Male
Medulla Oblongata.chemistry
Mesencephalon.chemistry
Pons.chemistry
Prosencephalon.chemistry
Rabbits
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Angiotensin.analysis
Thalamus.chemistry
Appears in Collections:Journal articles

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