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|Title:||Cortical hyperexcitability in progressive myoclonus epilepsy: a study with transcranial magnetic stimulation.|
|Authors:||Reutens, David C;Puce, Aina;Berkovic, Samuel F|
|Affiliation:||Department of Neurology, Austin Hospital, Melbourne, Victoria, Australia.|
|Citation:||Neurology; 43(1): 186-92|
|Abstract:||In progressive myoclonus epilepsy (PME), responses to afferent input are frequently abnormal. It is unclear whether the abnormality lies at the cortical, subcortical, or segmental level. To obtain evidence for an exaggerated effect on motor cortical excitability, we used peripheral nerve and transcranial magnetic stimulation in controls and subjects with idiopathic generalized epilepsy and PME. Mean threshold intensity was higher in those with idiopathic generalized epilepsy and PME than in controls, probably as a result of anticonvulsant treatment. A long-latency response to peripheral stimulation and an exaggerated facilitatory effect of peripheral stimulation on the motor evoked potential was present in subjects with PME. Latency differences between the late responses in the upper and lower limbs provided evidence against a segmental reflex and implicated rapidly conducting fibers in the spinal cord. Both the late response and the facilitatory effect had onset latencies consistent with a transcortical pathway, suggesting an exaggerated effect of afferent input on motor cortical excitability in PME.|
|Internal ID Number:||8423883|
Evoked Potentials, Somatosensory
Transcranial Magnetic Stimulation
|Appears in Collections:||Journal articles|
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