Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13360
Title: Angiotensin II, sodium, and cardiovascular hypertrophy in spontaneously hypertensive rats.
Authors: Harrap, Stephen B;Mitchell, G A;Casley, David J;Mirakian, C;Doyle, A E
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Jan-1993
Citation: Hypertension; 21(1): 50-5
Abstract: Angiotensin II (Ang II) may cause cardiovascular hypertrophy as a consequence of increased blood pressure or possibly by direct trophic actions. To dissociate Ang II and blood pressure in young spontaneously hypertensive rats (SHR), we used sodium loading during angiotensin converting enzyme inhibitor treatment. Animals were treated between 6 and 10 weeks of age with perindopril to lower Ang II and blood pressure, or with perindopril and 1% saline drinking fluid or perindopril and aldosterone infusion to lower Ang II but maintain high blood pressure. Blood pressure, heart weight, and media/lumen ratio of mesenteric resistance arteries were studied while rats were on treatment at 10 weeks of age and 15 weeks after treatment at 25 weeks of age. Perindopril lowered blood pressure and inhibited the development of cardiovascular hypertrophy. Saline or aldosterone restored high blood pressure during perindopril treatment and resulted in increased heart weight/body weight and resistance artery media/lumen ratios in direct proportion to the elevation of blood pressure. Because increased structure occurred despite perindopril treatment, we conclude that direct trophic actions of Ang II are not essential for the development of cardiovascular hypertrophy in young SHR and that the antitrophic actions of angiotensin converting enzyme inhibitors depend more on changes in blood pressure than on Ang II. However, restoration of blood pressure and structure by sodium during perindopril treatment raises the possibility that the design of the cardiovascular system and blood pressure may depend indirectly on Ang II through effects on sodium metabolism.
Internal ID Number: 8418023
URI: http://ahro.austin.org.au/austinjspui/handle/1/13360
URL: http://www.ncbi.nlm.nih.gov/pubmed/8418023
Type: Journal Article
Subjects: Angiotensin II.pharmacology
Animals
Blood Pressure.drug effects
Cardiomegaly.etiology.physiopathology
Hypertension.physiopathology
Indoles.pharmacology
Male
Perindopril
Rats
Rats, Inbred SHR
Sodium.pharmacology
Appears in Collections:Journal articles

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