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Title: Surgical damage stimulates proliferation of dopamine uptake sites in normal mouse brain.
Authors: Howells, David William;Donnan, Geoffrey A;Wong, J Y;Kaczmarczyk, S J;Chilcho, P J;Fabinyi, Gavin;Mendelsohn, Frederick AO
Affiliation: Department of Neurology, Austin Hospital, Heidelberg, Australia
Issue Date: 17-Sep-1993
Citation: Brain Research; 622(1-2): 285-8
Abstract: To test the hypothesis that proliferation of host dopaminergic tissue in response to injury plays an important role in the response to intrastriatal grafting, we transplanted autologous adrenal medullary to striatum in normal C57-black mice and compared this procedure with transplantation of non-dopaminergic tissue (frontal cortex) or a non-cellular matrix (Gelfoam). [3H]Mazindol autoradiography revealed that all three protocols resulted in a marked proliferation of dopamine uptake sites 10 months after transplantation.
Internal ID Number: 8242368
Type: Journal Article
Subjects: Adrenal Medulla.transplantation
Cerebral Cortex.transplantation
Gelatin Sponge, Absorbable
Mice, Inbred C57BL
Reference Values
Transplantation, Heterotopic.adverse effects
Appears in Collections:Journal articles

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