Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13264
Title: Progressive decline in renal function in diabetic patients with and without albuminuria.
Authors: Tsalamandris, Con;Allen, Terri J;Gilbert, Richard E;Sinha, A;Panagiotopoulos, Sianna;Cooper, Mark E;Jerums, George
Affiliation: Endocrine Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-May-1994
Citation: Diabetes; 43(5): 649-55
Abstract: This study describes patterns of progression of albuminuria and renal function in a subgroup of 40 patients from a total cohort of 211 diabetic patients (118 type I, 93 type II) followed over a period of 8-14 years. Forty patients (18 with type I diabetes, 22 with type II diabetes) showed progressive increases in albumin excretion rate (AER) and/or decreases in creatinine clearance (CC) during the study period. Of these, AER alone increased in 15 patients, AER increased and CC decreased in 13 patients, and CC alone decreased in 12 patients, with a similar distribution of type I and type II diabetic patients in each group. Of the 28 patients who showed an increase in albuminuria, AER increased at an annual rate of 30-40%, resulting in a 4- to 8-fold increase in AER to > 20 micrograms/min during the study. Of the 25 patients who showed a decrease in renal function, CC decreased at an annual rate of 4-5 ml/min, resulting in an approximate halving of CC to < 90 ml/min during the study. The rate of fall in CC was not related to the presence or absence of concomitant increases in albuminuria. However, a significant preponderance of women in the group showed a decline in CC alone. The decline in CC was associated with an increase in plasma creatinine as well as a progressive decrease in urinary creatinine excretion, but the underlying mechanisms remain unexplained. These data support the concept that a subgroup of diabetic patients may show a decline in renal function in the absence of significant increases in AER.(ABSTRACT TRUNCATED AT 250 WORDS)
Internal ID Number: 8168641
URI: http://ahro.austin.org.au/austinjspui/handle/1/13264
ORCID: 0000-0002-0845-0001
URL: http://www.ncbi.nlm.nih.gov/pubmed/8168641
Type: Journal Article
Subjects: Adult
Albuminuria
Blood Pressure
Body Weight
Creatinine.metabolism
Diabetes Mellitus, Type 1.blood.physiopathology.urine
Diabetes Mellitus, Type 2.blood.physiopathology.urine
Diabetic Nephropathies.blood.physiopathology.urine
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypertension.physiopathology
Kidney.physiopathology
Male
Middle Aged
Sex Factors
Time Factors
Appears in Collections:Journal articles

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