Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13262
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dc.contributor.authorPhillips, P A-
dc.contributor.authorBurrell, Louise M-
dc.contributor.authorRisvanis, John-
dc.contributor.authorStephenson, J-
dc.contributor.authorJohnston, Colin I-
dc.contributor.authorHutchins, A M-
dc.date.accessioned2015-05-16T03:05:00Z
dc.date.available2015-05-16T03:05:00Z
dc.date.issued1994-01-01-
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 21(1): 59-62en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13262en
dc.description.abstract1. The anti-emetic drug metoclopramide has been shown to stimulate secretion of the antidiuretic hormone arginine vasopressin. Since metoclopramide is used to treat nausea, which is another potent stimulus to vasopressin secretion, the aim of this study was to determine whether metoclopramide might limit free water excretion and so cause hyponatraemia. 2. Metoclopramide 20 mg (0.2-0.3 mg/kg), prochlorperazine 12.5 mg (0.1-0.2 mg/kg) and placebo were administered intravenously in a double blind randomized crossover way at 2 week intervals and the effects on urine flow rate, plasma osmolality, thirst ratings and plasma sodium and atrial natriuretic peptide concentrations determined in water-loaded (10 mL/kg) healthy young men. 3. There were no differential effects on any variable of either drug versus placebo. 4. These results indicate that metoclopramide is unlikely to cause any significant water retention in a clinical setting or precipitate hyponatraemia.en_US
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAtrial Natriuretic Factor.blooden
dc.subject.otherBody Water.metabolismen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherHumansen
dc.subject.otherInjections, Intravenousen
dc.subject.otherMaleen
dc.subject.otherMetoclopramide.administration & dosage.pharmacologyen
dc.subject.otherOsmolar Concentrationen
dc.subject.otherProchlorperazine.administration & dosage.pharmacologyen
dc.subject.otherSodium.blooden
dc.subject.otherThirsten
dc.subject.otherUrination.drug effectsen
dc.subject.otherWater-Electrolyte Balance.drug effectsen
dc.titleEffects of anti-emetics on water excretion in humans.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages59-62en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8156653en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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