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|Title:||Efficacy of 12 months' misoprostol as prophylaxis against NSAID-induced gastric ulcers. A placebo-controlled trial.|
|Authors:||Elliott, S L;Yeomans, Neville D;Buchanan, Russell R C;Smallwood, R A|
|Affiliation:||University of Melbourne Department of Medicine, Austin Repatriation Hospital, Australia.|
|Citation:||Scandinavian Journal of Rheumatology; 23(4): 171-6|
|Abstract:||We performed a 12-month, double-blind, randomised, placebo-controlled study to determine the long term effect of misoprostol (600-800 micrograms/d) in the prevention of gastric ulcers and gastroduodenal erosions in 83 arthritis patients on chronic NSAID therapy. Patients underwent endoscopy at 0, 3, 6 and 12 months. At the initial endoscopy, 12 patients had an ulcer (11 gastric), which was healed prior to randomization. Seventy eligible patients reached the 3 month endoscopy. Four (12.5%) of the 32 patients given misoprostol developed a gastric ulcer compared with 11 (28.9%) of the 38 on placebo (p < 0.05, life-table analysis). Six of the 11 patients with an initial gastric ulcer developed a further gastric ulcer, compared to 9 of 58 patients without an initial ulcer (p < 0.05). We conclude that misoprostol decreases the cumulative development of NSAID-induced gastric ulcers. Patients with a previous NSAID-ulcer have a higher risk of further ulceration.|
|Internal ID Number:||8091141|
Anti-Inflammatory Agents, Non-Steroidal.adverse effects
Misoprostol.administration & dosage.adverse effects
Stomach Ulcer.chemically induced.pathology.prevention & control
|Appears in Collections:||Journal articles|
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