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Title: Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder.
Authors: Norman, Trevor R;Apostolopoulos, M;Burrows, Graham D;Judd, F K
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 16-May-1994
Citation: International Clinical Psychopharmacology; 9(2): 89-94
Abstract: Prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-HT1A receptor, were measured in 16 patients with DSM-III-R obsessive-compulsive disorder (OCD) and 16 normal controls. No consistent differences were observed between patients and controls with respect to the hormone responses measured. The results suggest that dysfunction of the 5-HT1A receptor is not present in OCD patients. The limitations of buspirone as a specific agonist challenge of the 5-HT1A receptor are discussed. Although data from other studies generally support a serotonin dysfunction in OCD, the question of which specific subtype(s) of receptor remains unanswered.
Internal ID Number: 8056999
Type: Journal Article
Subjects: Adult
Buspirone.adverse effects.therapeutic use
Obsessive-Compulsive Disorder.drug therapy.physiopathology
Receptors, Serotonin.drug effects
Appears in Collections:Journal articles

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