Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13220
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dc.contributor.authorJackson, B-
dc.contributor.authorLiu, G-
dc.contributor.authorPerich, R B-
dc.contributor.authorPaxton, D-
dc.contributor.authorMcNicols, L-
dc.contributor.authorGutteridge, Geoffrey A-
dc.contributor.authorJohnston, Colin I-
dc.date.accessioned2015-05-16T03:01:58Z
dc.date.available2015-05-16T03:01:58Z
dc.date.issued1994-02-01-
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 21(2): 163-6en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13220en
dc.description.abstract1. The haemodynamic and hormonal responses of four patients with acute post-surgical oliguria (urine output < 0.5 mL/kg per h) were measured in response to the renin inhibitor enalkiren. Enalkiren was infused at 0.01 up to 0.1 mg/kg per h for up to 4 h. 2. Enalkiren infusion was associated with a progressive fall in blood pressure, clinically significant in three of the four patients. Systemic vascular resistance fell in proportion to blood pressure fall. Cardiac output and pulse rate remained unchanged. Effective renal plasma flow rose in all four cases (236 +/- 19 to 327 +/- 38). There was no change in urine flow rate, or urinary sodium excretion. 3. Plasma renin activity (ng angiotensin I/mL per h) fell from 1.9 +/- 0.5 to 0.02 +/- 0.01 (P < 0.04), plasma angiotensin II (pg/mL) fell from 104 +/- 93 to 7.7 +/- 1.5, and plasma aldosterone (ng/dL) fell from 32 +/- 8 to 21 +/- 9 (P = 0.03) at the highest infusion dose. 4. Enalkiren inhibited plasma renin activity with reduced plasma angiotensin II and aldosterone concentrations. This was associated with vasodilation, reduced blood pressure and maintained cardiac output. There was no beneficial effect on renal function in these patients with post-surgical oliguria.en_US
dc.language.isoenen
dc.subject.otherAldosterone.blooden
dc.subject.otherAngiotensin II.blooden
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCardiac Output.drug effectsen
dc.subject.otherCoronary Artery Bypassen
dc.subject.otherDipeptides.administration & dosage.adverse effects.therapeutic useen
dc.subject.otherHemodynamics.drug effectsen
dc.subject.otherHormones.blooden
dc.subject.otherHumansen
dc.subject.otherKidney.drug effectsen
dc.subject.otherOliguria.drug therapy.physiopathologyen
dc.subject.otherPostoperative Complications.drug therapy.physiopathologyen
dc.subject.otherPulse.drug effectsen
dc.subject.otherRenal Plasma Flow, Effective.drug effectsen
dc.subject.otherRenin.antagonists & inhibitors.blooden
dc.subject.otherRenin-Angiotensin System.drug effectsen
dc.subject.otherVascular Resistance.drug effectsen
dc.titleHaemodynamic, renal and hormonal responses to enalkiren in four patients with post-surgical oliguria.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages163-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8039272en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherJackson, Belinda D
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
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