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Title: | Transplantation studies of the role of the kidney in long-term blood pressure reduction following brief ACE inhibitor treatment in young spontaneously hypertensive rats. | Austin Authors: | Harrap, Stephen B;Wang, B Z;MacLellan, D G | Affiliation: | Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Feb-1994 | Publication information: | Clinical and Experimental Pharmacology & Physiology; 21(2): 129-31 | Abstract: | 1. Brief treatment with angiotensin-converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a persistent reduction in blood pressure associated with a relatively selective reduction in renal vascular resistance. 2. To study the possible role of the kidney in this long-term hypotensive effect, we transplanted kidneys from untreated SHR into SHR that had been treated with perindopril (3 mg/kg per day) between 6 and 10 weeks of age and also transplanted kidneys from perindopril-pretreated SHR into untreated SHR. After transplantation, the remaining native kidney was removed so that only donor kidneys remained. 3. Untreated SHR that received kidneys from perindopril-pretreated SHR showed an initial fall in blood pressure followed by a rapid increase in pressure, weight loss and early death. 4. The transplantation of kidneys from control SHR into perindopril-pretreated SHR resulted in a rise in blood pressure that obviated the long-term reduction seen normally in these animals. 5. Kidneys from perindopril-pretreated SHR may be susceptible to the high blood pressure in untreated SHR. 6. The blood pressure increase in perindopril-pretreated SHR that accompanies substitution of the native kidneys by kidneys from untreated SHR further supports the hypothesis that the kidney is responsible for the long-term pressure effects following ACE inhibition in young SHR. | Gov't Doc #: | 8039265 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13219 | Journal: | Clinical and Experimental Pharmacology & Physiology | URL: | https://pubmed.ncbi.nlm.nih.gov/8039265 | Type: | Journal Article | Subjects: | Aging.physiology Angiotensin-Converting Enzyme Inhibitors.pharmacology Animals Blood Pressure.drug effects Indoles.pharmacology Kidney.physiology Kidney Transplantation.physiology Male Nephrectomy Perindopril Rats Rats, Inbred SHR Renal Circulation.drug effects Vascular Resistance.drug effects |
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