Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13214
Title: Familial CREST syndrome.
Authors: McColl, G J;Buchanan, Russell R C
Affiliation: University of Melbourne, Department of Rheumatology, Austin Hospital, Australia.
Issue Date: 1-Apr-1994
Citation: The Journal of Rheumatology; 21(4): 754-6
Abstract: The familial occurrence of scleroderma is uncommon particularly the limited (CREST) form. We describe 2 families in which such an association occurred. Family pedigree 1 consists of 2 of 3 sisters with CREST scleroderma. Both affected sisters shared HLA types and C4 allotypes including DR5, found more frequently in patients with scleroderma. The unaffected sister did not share this MHC allele. Family pedigree 2 includes a grandmother and grandson with CREST scleroderma as well as a family member with Raynaud's phenomena alone. We conclude that familial occurrence of scleroderma may be associated with shared class II MHC antigens.
Internal ID Number: 8035406
URI: http://ahro.austin.org.au/austinjspui/handle/1/13214
URL: http://www.ncbi.nlm.nih.gov/pubmed/8035406
Type: Journal Article
Subjects: Adult
Aged
CREST Syndrome.genetics.immunology
Female
Genetic Markers
HLA Antigens.genetics
HLA-DR5 Antigen.genetics
Humans
Male
Pedigree
Appears in Collections:Journal articles

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