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Title: A stable leukocyte-derived factor inhibits platelet aggregation.
Authors: Liu, J J;Xie, B;Smith, I L;Johnston, Colin I;Buxton, Brian F
Affiliation: University of Melbourne, Austin Hospital Department of Cardiac Surgery, Heidelberg, Vic., Australia.
Issue Date: 15-Jun-1994
Citation: Biochemical and Biophysical Research Communications; 201(2): 878-82
Abstract: The effect of human polymorphonuclear leukocyte (PMN)-derived supernatants on platelet aggregation was studied. The results showed that the supernatants produced a concentration-dependent inhibition of the platelet aggregation in response to thrombin. The effect was mainly on the second phase of the aggregation, suggesting that the secretory mechanisms of the platelets are disturbed. The activity of the supernatants was not reduced after treatment with heat (95 degrees C for 30 minutes), extreme pH (pH 12 or pH 2) or protease. In conclusion, human PMNs release a stable non-protein factor that inhibits platelet aggregation.
Internal ID Number: 8003026
DOI: 10.1006/bbrc.1994.1783
Type: Journal Article
Subjects: Biological Factors.blood.physiology
Blood Platelets.drug effects.physiology
In Vitro Techniques
Platelet Aggregation.drug effects.physiology
Tissue Extracts.pharmacology
Appears in Collections:Journal articles

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