Please use this identifier to cite or link to this item:
|Title:||A stable leukocyte-derived factor inhibits platelet aggregation.|
|Authors:||Liu, J J;Xie, B;Smith, I L;Johnston, Colin I;Buxton, Brian F|
|Affiliation:||University of Melbourne, Austin Hospital Department of Cardiac Surgery, Heidelberg, Vic., Australia.|
|Citation:||Biochemical and Biophysical Research Communications; 201(2): 878-82|
|Abstract:||The effect of human polymorphonuclear leukocyte (PMN)-derived supernatants on platelet aggregation was studied. The results showed that the supernatants produced a concentration-dependent inhibition of the platelet aggregation in response to thrombin. The effect was mainly on the second phase of the aggregation, suggesting that the secretory mechanisms of the platelets are disturbed. The activity of the supernatants was not reduced after treatment with heat (95 degrees C for 30 minutes), extreme pH (pH 12 or pH 2) or protease. In conclusion, human PMNs release a stable non-protein factor that inhibits platelet aggregation.|
|Internal ID Number:||8003026|
Blood Platelets.drug effects.physiology
In Vitro Techniques
Platelet Aggregation.drug effects.physiology
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.