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Title: Microalbuminuria: prognostic and therapeutic implications in diabetes mellitus.
Authors: Gilbert, Richard E;Cooper, Mark E;McNally, P G;O'Brien, R C;Taft, J;Jerums, George
Affiliation: Endocrinology Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 9-Aug-1994
Citation: Diabetic Medicine : A Journal of the British Diabetic Association; 11(7): 636-45
Abstract: Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular morbidity and mortality.
Internal ID Number: 7955987
Type: Journal Article
Subjects: Albuminuria.epidemiology.physiopathology
Blood Glucose.metabolism
Blood Pressure
Cost-Benefit Analysis
Diabetes Mellitus.physiopathology.therapy.urine
Diabetic Nephropathies.economics.physiopathology.prevention & control
United States
Appears in Collections:Journal articles

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