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|Title:||Lack of direct action of D-fenfluramine on arcuate preproNPY mRNA levels in the rat.|
|Authors:||O'Shea, R D;Gundlach, Andrew L|
|Affiliation:||University of Melbourne, Department of Medicine, Austin and Heidelberg Repatriation Hospitals, Vic., Australia.|
|Citation:||Neuroreport; 5(16): 2113-6|
|Abstract:||Hypothalamic neuropeptide Y (NPY) and 5-hydroxytryptamine (5-HT) may interact to regulate food intake. This study investigated the effects of the 5-HT reuptake blocker and secretagogue D-fenfluramine (D-FEN) on preproNPY mRNA abundance in the hypothalamic arcuate nucleus (ARC) of free-feeding and food-deprived (FD) rats in two treatment regimens. ARC preproNPY mRNA levels were significantly increased in FD rats, to the same extent as in combined FD/D-FEN animals. D-FEN treatments producing different-sized reductions in food intake (and body weight) produced corresponding changes in ARC preproNPY mRNA abundance. These findings suggest that ARC preproNPY mRNA levels are not directly altered by D-FEN, and that D-FEN-induced anorexia does not involve effects on the hypothalamic NPY system at the level of NPY gene transcription.|
|Internal ID Number:||7865757|
Arcuate Nucleus of Hypothalamus.drug effects.metabolism
Body Weight.drug effects
|Appears in Collections:||Journal articles|
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