Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13123
Title: Antibody-targeted drugs for the therapy of cancer.
Authors: Pietersz, Geoffrey A;Krauer, K G
Affiliation: Austin Research Institute, Austin Hospital, Heidelberg Vic, Australia.
Issue Date: 16-May-1994
Citation: Journal of Drug Targeting; 2(3): 183-215
Abstract: The advent of monoclonal antibodies has revitalised the concept of magic bullets and various agents (eg. drugs, toxins and isotopes) have been conjugated to monoclonal antibodies for selective delivery to tumours. Preclinical studies in mouse tumour models have been impressive and have lead to several clinical trials. These phase I trials have been less impressive. However, keeping in mind the aim of Phase I trials, the safety of using these conjugates in humans have been established. Several, major problems still remain to be overcome before these agents may be useful for the treatment of cancer. These problems stem from the nature of tumour vasculature, cytotoxic activity of the moiety linked to antibody and the targeted tumour antigen expressed on the cell surface. This review will deal with these various aspects described above and possible approaches to overcome these obstacles with a definite bias towards drug-monoclonal antibody conjugates. However, these concepts are equally applicable for improved targeting of other agents.
Internal ID Number: 7812691
URI: http://ahro.austin.org.au/austinjspui/handle/1/13123
DOI: 10.3109/10611869408996804
URL: http://www.ncbi.nlm.nih.gov/pubmed/7812691
Type: Journal Article
Subjects: Animals
Antibodies, Monoclonal.immunology.metabolism.therapeutic use
Antibodies, Neoplasm.genetics.metabolism
Antibody Specificity
Antigen-Antibody Reactions
Antigens, Neoplasm.genetics.metabolism
Antineoplastic Agents.metabolism.therapeutic use
Disease Models, Animal
Gene Expression Regulation, Neoplastic
Humans
Immunoconjugates.adverse effects.genetics.therapeutic use.toxicity
Mice
Neoplasms.drug therapy
Appears in Collections:Journal articles

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