Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13116
Title: Angiotensin II receptor subtypes in the human central nervous system.
Authors: MacGregor, Duncan;Murone, Carmel;Song, K;Allen, A M;Paxinos, G;Mendelsohn, Frederick AO
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Australia.
Issue Date: 27-Mar-1995
Citation: Brain Research; 675(1-2): 231-40
Abstract: The distribution of the AT1 and AT2 subtypes of angiotensin II receptor was mapped in the adult human central nervous system using quantitative in vitro autoradiography. Binding in all forebrain, midbrain, pontine, medullary and spinal cord sites where angiotensin II receptors have previously been described is of the AT1 subtype, as is binding in the small and large arteries in the adjacent meninges and in choroid plexus. By contrast, both AT1 and AT2 receptors occur in the molecular layer of the cerebellum. Angiotensin II AT1 receptors in the brain show a moderate degree of conservation across mammalian species studied so far, whereas expression of AT2 receptors is more variable, and is more restricted in the human CNS than in many other mammals. These differences between the subtype distributions in humans and other animals indicate the need for care when extrapolating the results of animal studies involving the brain angiotensin system.
Internal ID Number: 7796134
URI: http://ahro.austin.org.au/austinjspui/handle/1/13116
URL: http://www.ncbi.nlm.nih.gov/pubmed/7796134
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Angiotensin II.antagonists & inhibitors.metabolism
Angiotensin Receptor Antagonists
Autoradiography
Biphenyl Compounds.pharmacology
Brain.drug effects.metabolism
Central Nervous System.drug effects.metabolism
Female
Humans
Imidazoles.pharmacology
Losartan
Male
Pyridines.pharmacology
Radioligand Assay
Receptors, Angiotensin.agonists.metabolism
Spinal Cord.drug effects.metabolism
Tetrazoles.pharmacology
Appears in Collections:Journal articles

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