Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13113
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNg, C Y-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorGhabrial, Hany-
dc.contributor.authorChou, S T-
dc.contributor.authorArnolda, L-
dc.contributor.authorMorgan, Denis J-
dc.contributor.authorSmallwood, R A-
dc.date.accessioned2015-05-16T02:53:49Z
dc.date.available2015-05-16T02:53:49Z
dc.date.issued1995-06-01-
dc.identifier.citationThe Journal of Pharmacology and Experimental Therapeutics; 273(3): 1332-6en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13113en
dc.description.abstractThe effect of right heart failure on theophylline clearance was investigated in rats in which right ventricular pressure overload was produced by pulmonary artery constriction (PAC). Fifteen wk after the surgery, compared to sham-operated controls (n = 9), PAC rats (n = 9) showed markedly elevated mean central venous pressure (11 +/- 3 vs 1.44 +/- 0.88 mm Hg, P = .0001), and increased right ventricular weight (0.229 +/- 0.047 vs 0.124 +/- 0.013 g/100 g body weight, P = .0001). Centrilobular hepatic congestion was present in all PAC rats and total hepatic oxygen delivery was reduced significantly compared to controls (146 +/- 58 mumols/min vs. 206 +/- 28 mumol/min; P = .025). In the PAC group, theophylline clearance was reduced (0.82 +/- 0.12 ml/min vs. 0.96 +/- 0.13 ml/min in controls; P = .014), and there was a nonlinear correlation between theophylline clearance and total hepatic oxygen delivery (r = .82). These results suggest that in animals with PAC, metabolism of theophylline was impaired as a result of a reduction in total hepatic oxygen delivery. Therefore, in addition to the known effect of reduced hepatic blood flow on the hepatic clearance of "flow limited" drugs, reduction of hepatic oxygen delivery may be another important mechanism that can lead to reduction in hepatic clearance of capacity-limited drugs in congestive heart failure.en_US
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCardiac Output, Low.metabolismen
dc.subject.otherLiver.metabolismen
dc.subject.otherMaleen
dc.subject.otherOxidation-Reductionen
dc.subject.otherOxygen.metabolismen
dc.subject.otherPulmonary Artery.physiopathologyen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherTheophylline.pharmacokineticsen
dc.titleRight heart failure impairs hepatic oxygenation and theophylline clearance in rats.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe Journal of Pharmacology and Experimental Therapeuticsen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages1332-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7791105en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.