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|Title:||The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions.|
|Authors:||Komersova, K;Rogerson, J W;Conway, Elizabeth L;Lim, T C;Brown, Douglas J;Krum, Henry;Jackman, G P;Murdoch, R;Louis, William J|
|Affiliation:||Department of Clinical Pharmacology and Therapeutics, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||British Journal of Clinical Pharmacology; 39(2): 207-9|
|Abstract:||The effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically.|
|Internal ID Number:||7742166|
Analysis of Variance
Blood Pressure.drug effects
Potassium Channels.drug effects
Spinal Cord Injuries.physiopathology
Urinary Bladder, Neurogenic.physiopathology
|Appears in Collections:||Journal articles|
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