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https://ahro.austin.org.au/austinjspui/handle/1/13098
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Armes, J E | en |
dc.contributor.author | Eades, S | en |
dc.contributor.author | Southey, M C | en |
dc.contributor.author | Ross, B C | en |
dc.contributor.author | Carapetis, J R | en |
dc.contributor.author | Chow, C W | en |
dc.contributor.author | Venter, D J | en |
dc.date.accessioned | 2015-05-16T02:52:49Z | |
dc.date.available | 2015-05-16T02:52:49Z | |
dc.date.issued | 1995-03-01 | en |
dc.identifier.citation | Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B; 4(1): 39-47 | en |
dc.identifier.govdoc | 7735554 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13098 | en |
dc.description.abstract | We report a case of a 21-year-old woman with hematopoietic, immunological, and congenital dysmorphic abnormalities, who died following rapidly progressive, disseminated Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement. PCR analysis also demonstrated that all lesions contained EBV genome. Since DNA had been extracted from paraffin blocks, a direct comparison of morphology and clonality could be made in each individual lesion. The evidence from this study indicates that the monoclonal tumors arose de novo in multiple sites and that the polyclonal background observed in some lesions reflected a substantial concomitant inflammatory response. | en |
dc.language.iso | en | en |
dc.subject.other | Blotting, Southern | en |
dc.subject.other | Clone Cells | en |
dc.subject.other | DNA, Viral.isolation & purification | en |
dc.subject.other | Female | en |
dc.subject.other | Herpesviridae Infections.blood.immunology.pathology | en |
dc.subject.other | Herpesvirus 4, Human.isolation & purification | en |
dc.subject.other | Humans | en |
dc.subject.other | Infant | en |
dc.subject.other | Lymphoproliferative Disorders.blood.immunology.pathology.virology | en |
dc.subject.other | Polymerase Chain Reaction | en |
dc.subject.other | Tumor Virus Infections.blood.immunology.pathology | en |
dc.title | Disseminated, multiclonal Epstein-Barr virus-associated lymphoproliferative disease in a patient with hematological and immunological anomalies. Molecular analysis correlates with morphological appearance. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Diagnostic molecular pathology : the American journal of surgical pathology, part B | en |
dc.identifier.affiliation | Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 39-47 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/7735554 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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