Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13098
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dc.contributor.authorArmes, J Een
dc.contributor.authorEades, Sen
dc.contributor.authorSouthey, M Cen
dc.contributor.authorRoss, B Cen
dc.contributor.authorCarapetis, J Ren
dc.contributor.authorChow, C Wen
dc.contributor.authorVenter, D Jen
dc.date.accessioned2015-05-16T02:52:49Z
dc.date.available2015-05-16T02:52:49Z
dc.date.issued1995-03-01en
dc.identifier.citationDiagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B; 4(1): 39-47en
dc.identifier.govdoc7735554en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13098en
dc.description.abstractWe report a case of a 21-year-old woman with hematopoietic, immunological, and congenital dysmorphic abnormalities, who died following rapidly progressive, disseminated Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement. PCR analysis also demonstrated that all lesions contained EBV genome. Since DNA had been extracted from paraffin blocks, a direct comparison of morphology and clonality could be made in each individual lesion. The evidence from this study indicates that the monoclonal tumors arose de novo in multiple sites and that the polyclonal background observed in some lesions reflected a substantial concomitant inflammatory response.en
dc.language.isoenen
dc.subject.otherBlotting, Southernen
dc.subject.otherClone Cellsen
dc.subject.otherDNA, Viral.isolation & purificationen
dc.subject.otherFemaleen
dc.subject.otherHerpesviridae Infections.blood.immunology.pathologyen
dc.subject.otherHerpesvirus 4, Human.isolation & purificationen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherLymphoproliferative Disorders.blood.immunology.pathology.virologyen
dc.subject.otherPolymerase Chain Reactionen
dc.subject.otherTumor Virus Infections.blood.immunology.pathologyen
dc.titleDisseminated, multiclonal Epstein-Barr virus-associated lymphoproliferative disease in a patient with hematological and immunological anomalies. Molecular analysis correlates with morphological appearance.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiagnostic molecular pathology : the American journal of surgical pathology, part Ben
dc.identifier.affiliationDepartment of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages39-47en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7735554en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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