Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13098
Title: Disseminated, multiclonal Epstein-Barr virus-associated lymphoproliferative disease in a patient with hematological and immunological anomalies. Molecular analysis correlates with morphological appearance.
Authors: Armes, J E;Eades, S;Southey, M C;Ross, B C;Carapetis, J R;Chow, C W;Venter, D J
Affiliation: Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Mar-1995
Citation: Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B; 4(1): 39-47
Abstract: We report a case of a 21-year-old woman with hematopoietic, immunological, and congenital dysmorphic abnormalities, who died following rapidly progressive, disseminated Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement. PCR analysis also demonstrated that all lesions contained EBV genome. Since DNA had been extracted from paraffin blocks, a direct comparison of morphology and clonality could be made in each individual lesion. The evidence from this study indicates that the monoclonal tumors arose de novo in multiple sites and that the polyclonal background observed in some lesions reflected a substantial concomitant inflammatory response.
Internal ID Number: 7735554
URI: http://ahro.austin.org.au/austinjspui/handle/1/13098
URL: http://www.ncbi.nlm.nih.gov/pubmed/7735554
Type: Journal Article
Subjects: Blotting, Southern
Clone Cells
DNA, Viral.isolation & purification
Female
Herpesviridae Infections.blood.immunology.pathology
Herpesvirus 4, Human.isolation & purification
Humans
Infant
Lymphoproliferative Disorders.blood.immunology.pathology.virology
Polymerase Chain Reaction
Tumor Virus Infections.blood.immunology.pathology
Appears in Collections:Journal articles

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