Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13097
Title: Interactions of angiotensin II with central catecholamines.
Authors: Jenkins, T A;Allen, A M;Chai, Syn Y;Mendelsohn, Frederick AO
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital Heidelberg, Victoria.
Issue Date: 2-Jan-1995
Citation: Clinical and Experimental Hypertension (new York, N.y. : 1993); 17(1-2): 267-80
Abstract: There is a large body of anatomical and functional evidence supporting an interaction between brain angiotensin and central catecholamine systems. Angiotensin II AT1 receptors have been identified on dopamine containing cells in the substantia nigra and striatum of human brain using receptor autoradiography. Using in vivo microdialysis we have demonstrated that locally administered angiotensin II stimulates dopamine release from the striatum of conscious rats. Since some angiotensin receptor antagonists and angiotensin converting enzyme inhibitors can cross the blood brain barrier it is possible that they interact with the brain catecholaminergic systems.
Internal ID Number: 7735274
URI: http://ahro.austin.org.au/austinjspui/handle/1/13097
URL: http://www.ncbi.nlm.nih.gov/pubmed/7735274
Type: Journal Article
Subjects: Angiotensin II.physiology
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors.pharmacology
Animals
Biphenyl Compounds.pharmacology
Brain.drug effects.physiology
Catecholamines.physiology
Dopamine.physiology
Humans
Imidazoles.pharmacology
Losartan
Rats
Tetrazoles.pharmacology
Appears in Collections:Journal articles

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