Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13085
Title: Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients.
Authors: O'Callaghan, Christopher J;Krum, Henry;Conway, Elizabeth L;Lam, W;Skiba, M A;Howes, L G;Louis, William J
Affiliation: Hypertension Services, Austin Hospital, Heidelberg, Australia.
Issue Date: 1-Nov-1994
Citation: Blood Pressure; 3(6): 404-6
Abstract: In this study, which was primarily designed to determine the lipid-lowering efficacy of pravastatin in the setting of background antihypertensive therapy with ACE inhibitors and calcium antagonists, we took the opportunity to examine whether pravastatin interacts with antihypertensive therapy to produce additional falls in blood pressure. This may help clarify the mechanism of action of pravastatin's rapid beneficial effects on cardiovascular morbidity. We treated 25 hypertensive hypercholesterolaemic patients with 12 weeks of either pravastatin or placebo in this double blind, placebo controlled parallel group study. Placebo treatment did not alter plasma lipids, whereas 12 weeks' treatment with pravastatin reduced total cholesterol by 27% (from 7.1 +/- 0.27 to 5.2 +/- 0.18, p < 0.001 compared with placebo) and low density lipoprotein cholesterol by 35% (from 4.9 +/- 0.36 to 3.2 +/- 0.17, p < 0.001). There were no changes in systolic or diastolic blood pressure either following 12 weeks' treatment or 3 weeks' withdrawal of pravastatin. Thus, pravastatin remains efficacious as a lipid lowering agent in the presence of antihypertensive therapy but does not enhance the blood pressure lowering action of these drugs. Therefore it is unlikely that blood pressure reduction is the mechanism by which pravastatin mediates its reported short term effects on cardiovascular morbidity.
Internal ID Number: 7704289
URI: http://ahro.austin.org.au/austinjspui/handle/1/13085
URL: http://www.ncbi.nlm.nih.gov/pubmed/7704289
Type: Journal Article
Subjects: Blood Pressure.drug effects
Captopril.pharmacology.therapeutic use
Cholesterol.blood
Cholesterol, LDL.blood
Combined Modality Therapy
Double-Blind Method
Drug Interactions
Felodipine.pharmacology.therapeutic use
Female
Humans
Hypercholesterolemia.blood.complications.diet therapy.drug therapy.physiopathology
Hypertension.blood.complications.drug therapy.physiopathology
Lipids.blood
Male
Middle Aged
Pravastatin.pharmacology.therapeutic use
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.