Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13074
Title: Effect of dorsal periaqueductal grey lesion on baroreflex and cardiovascular response to air-jet stress.
Authors: Lam, W;Louis, William J;Verberne, Anthony J M
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 17-May-1995
Citation: Journal of the Autonomic Nervous System; 53(1): 35-42
Abstract: Certain areas within the periaqueductal grey (PAG) have been implicated in cardiovascular regulation. The influence of excitotoxic lesions of the caudal dorsal periaqueductal grey on the baroreceptor-heart rate reflex and the cardiovascular response to air-jet stress was examined in awake Wistar-Kyoto rats. Pressor (11 +/- 2 mmHg) and tachycardic (25 +/- 4 beats/min) responses to air-jet were not influenced by the lesion. Similarly, the resting MAP and HR were unchanged. However, the gain of the baroreflex was reduced from -3.9 +/- 0.1 to -2.8 +/- 0.3 beats/min per mmHg and the upper threshold was increased from 120 +/- 5 to 135 +/- 7 mmHg in the lesioned group. These observations suggest that although the caudal dorsal PAG does not appear to exert a tonic influence on vasomotor tone or mediate the air-jet response, it may provide a facilitatory input to the baroreceptor-heart rate reflex.
Internal ID Number: 7673600
URI: http://ahro.austin.org.au/austinjspui/handle/1/13074
URL: http://www.ncbi.nlm.nih.gov/pubmed/7673600
Type: Journal Article
Subjects: Animals
Baroreflex.physiology
Blood Pressure.physiology
Heart Rate.physiology
Hemodynamics.physiology
Male
N-Methylaspartate.toxicity
Periaqueductal Gray.anatomy & histology.physiology
Physical Stimulation
Rats
Rats, Inbred WKY
Stereotaxic Techniques
Stress, Physiological.physiopathology
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.