Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13064
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dc.contributor.authorYou, Ren
dc.contributor.authorMcNeil, John Jen
dc.contributor.authorO'Malley, H Men
dc.contributor.authorDavis, S Men
dc.contributor.authorDonnan, Geoffrey Aen
dc.date.accessioned2015-05-16T02:50:33Z
dc.date.available2015-05-16T02:50:33Z
dc.date.issued1995-08-01en
dc.identifier.citationNeurology; 45(8): 1483-7en
dc.identifier.govdoc7644045en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13064en
dc.description.abstractLacunar infarction is an important stroke subgroup with unique clinical and pathologic features, but its relative risks for associated risk factors have been rarely documented. To address this matter, we studied 203 consecutive patients with first-ever stroke due to lacunar infarction admitted to four general hospitals during the period 1985 to 1992.We obtained information concerning risk factor exposure status among the patients by interview using a structured questionnaire and by comparison with age- and sex-matched neighborhood controls. Odds ratios were estimated with adjustment for confounding variables by using multivariate logistic regression.Significantly increasing the risk of lacunar stroke were hypertension (with an odds ratio of 8.9 [95% confidence intervals 4.2, 18.8]), current smoking (6.6 [2.9, 14.8]), and diabetes (2.3 [1.0, 5.5]), whereas frequent physical exercise was associated with a significantly decreased risk (0.3 [0.1, 0.7]). There was no risk of lacunar stroke associated with heart disease (odds ratio 1.0 [0.5, 1.9]).Patients with hypertension or diabetes, and those who currently smoke, are at a higher risk of lacunar stroke, whereas those who undertake regular physical exercise may be at lower risk. The high risk associated with hypertension but absent risk with heart disease supports the "lacunar hypothesis" of a unique pathophysiologic mechanism for lacunar stroke.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherCerebral Infarction.epidemiology.etiologyen
dc.subject.otherDiabetes Complicationsen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypertension.complicationsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMultivariate Analysisen
dc.subject.otherPhysical Exertionen
dc.subject.otherRegression Analysisen
dc.subject.otherRisk Factorsen
dc.subject.otherSmoking.adverse effectsen
dc.subject.otherSyndromeen
dc.titleRisk factors for lacunar infarction syndromes.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.description.pages1483-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7644045en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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