Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13063
Title: Idiopathic generalized epilepsy of adolescence: are the syndromes clinically distinct?
Authors: Reutens, David C;Berkovic, Samuel F
Affiliation: Department of Neurology, Austin Hospital, Heidelberg (Melbourne), Victoria, Australia.
Issue Date: 1-Aug-1995
Citation: Neurology; 45(8): 1469-76
Abstract: Juvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy with generalized tonic-clonic seizures (GTCS) on awakening are the three syndromes of idiopathic generalized epilepsy of adolescent onset currently included in the classification of epilepsy syndromes of the International League Against Epilepsy (ILAE). Although they differ in their predominant seizure types, the syndromes share several clinical features, thus giving rise to questions of phenotypic overlap and purity. We studied the clinical features of 101 patients with idiopathic generalized epilepsy beginning in adolescence. A standardized interview was used to elucidate seizure phenomenology, precipitants, frequency, and response to treatment. Groups defined by seizure type were compared and their similarities examined. The group with myoclonic but not absence seizures (21 patients) corresponded to the ILAE syndrome of juvenile myoclonic epilepsy, whereas those with absences but not myoclonus (37 patients) resembled juvenile absence epilepsy. Twenty-six patients shared the features of juvenile myoclonic epilepsy and juvenile absence epilepsy. Epilepsy with GTCS on awakening was not a specific syndromic entity; 10 patients had this seizure type alone. Seven patients were without a syndromic diagnosis. In these patients only GTCS occurred, but neither on awakening nor in the evening period of relaxation. We conclude that whilst syndromes of idiopathic generalized epilepsy of adolescence can be recognized, the current classification does not include all patients. In addition, the boundaries between the syndromes are indistinct, suggesting underlying neurobiological, possibly genetic, relationships.
Internal ID Number: 7644043
URI: http://ahro.austin.org.au/austinjspui/handle/1/13063
URL: http://www.ncbi.nlm.nih.gov/pubmed/7644043
Type: Journal Article
Subjects: Adolescent
Adult
Age of Onset
Child
Epilepsies, Myoclonic.classification.complications
Epilepsy.classification
Epilepsy, Absence.classification.complications
Epilepsy, Generalized.diagnosis.physiopathology.therapy
Epilepsy, Tonic-Clonic.classification
Female
Humans
Interviews as Topic
Male
Syndrome
Appears in Collections:Journal articles

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