Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13056
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dc.contributor.authorBaird, A Een
dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorAustin, M Cen
dc.contributor.authorMcKay, W Jen
dc.date.accessioned2015-05-16T02:50:01Z
dc.date.available2015-05-16T02:50:01Z
dc.date.issued1995-07-01en
dc.identifier.citationNeurology; 45(7): 1335-9en
dc.identifier.govdoc7617194en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13056en
dc.description.abstractThe "spectacular shrinking deficit" (SSD) refers to a syndrome of profound hemispheric ischemia that resolves rapidly over hours to days, leaving patients with minimal residual neurologic deficits. The SSD is postulated to result from rapid embolic lysis, fragmentation, and migration along the internal carotid/middle cerebral artery axis, leading to restored tissue perfusion before irreversible tissue damage has occurred. We performed serial single-photon emission computed tomographic (SPECT) cerebral perfusion measurements during the first 48 hours in 36 patients admitted with major hemispheric ischemia, to compare the cerebral perfusion changes between patients who developed SSD (n = 5) and those who did not (n = 31). The two groups were similar for severity of neurologic deficit, time of SPECT study, and size of perfusion defect on the SPECT images. Patients with SSD were younger (p = 0.02, Mann-Whitney U), demonstrated significantly greater tissue reperfusion during the first 48 hours (p < 0.01), and had smaller infarcts on CT (p = 0.02). This syndrome provides an opportunity to understand the mechanism by which early reperfusion may result in early tissue salvage and clinical recovery.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherBrain Ischemia.physiopathology.radionuclide imagingen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherOrganotechnetium Compounds.diagnostic useen
dc.subject.otherOximes.diagnostic useen
dc.subject.otherTechnetium Tc 99m Exametazimeen
dc.subject.otherTomography, Emission-Computed, Single-Photonen
dc.titleEarly reperfusion in the 'spectacular shrinking deficit' demonstrated by single-photon emission computed tomography.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, Melbourne, Victoria, Australiaen
dc.description.pages1335-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7617194en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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