Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13047
Title: End-organ involvement and calcium antagonist therapy: animal studies.
Authors: Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 16-May-1994
Citation: Journal of Cardiovascular Pharmacology; 24 Suppl A(): S12-7
Abstract: Hypertension is a complex disease, the treatment of which should not only lower systolic and diastolic blood pressure but also attenuate the secondary consequences of the disease. These include vascular injury (including atherosclerosis), stroke, left ventricular hypertrophy, and renal damage. To establish whether the long-acting, vascular-selective calcium antagonist amlodipine attenuates some of these secondary consequences of hypertension, 5-week-old stroke-prone hypertensive and 8-week-old spontaneously hypertensive rats were treated (orally) with 5 mg/kg/day and 10 mg/kg/day amlodipine, respectively, for 30 weeks. The treatment resulted in a significant lowering of systolic blood pressure, accompanied by reduced cardiac hypertrophy and prolonged survival. Evidence for a protective effect of amlodipine on the vasculature was obtained by treating cholesterol-fed rabbits with 1-5 mg/kg/body weight/day. This resulted in a reduction in vascular Ca2+ overloading and a reduced incidence of sudanophilic lesion formation. Protection against ischemia-induced changes in the myocardium included a reduction in the ischemia-induced externalization of endothelin-1 binding sites.
Internal ID Number: 7603072
URI: http://ahro.austin.org.au/austinjspui/handle/1/13047
URL: http://www.ncbi.nlm.nih.gov/pubmed/7603072
Type: Journal Article
Subjects: Administration, Oral
Amlodipine.administration & dosage.pharmacology.therapeutic use
Animals
Aorta, Thoracic.drug effects.metabolism.pathology
Arteriosclerosis.etiology.prevention & control
Binding Sites
Blood Pressure.drug effects
Calcium.analysis
Cardiomegaly.mortality.prevention & control
Cholesterol.analysis
Cholesterol, Dietary.administration & dosage
Disease Models, Animal
Endothelins.metabolism
Hypertension.complications.drug therapy.mortality
Male
Myocardial Ischemia.drug therapy.metabolism
Myocardial Reperfusion Injury.drug therapy.metabolism
Rabbits
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Appears in Collections:Journal articles

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