Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13045
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dc.contributor.authorBurrell, Louise M-
dc.contributor.authorPhillips, P A-
dc.contributor.authorRisvanis, John-
dc.contributor.authorAldred, K L-
dc.contributor.authorHutchins, A M-
dc.contributor.authorJohnston, Colin I-
dc.date.accessioned2015-05-16T02:49:17Z
dc.date.available2015-05-16T02:49:17Z
dc.date.issued1995-11-01-
dc.identifier.citationHypertension; 26(5): 828-34en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13045en
dc.description.abstractAbnormalities of the vasopressin system are found in genetic hypertension. This study compares the delayed effects of a brief period of vasopressin V1A receptor blockade and angiotensin-converting enzyme inhibition in young female and male spontaneously hypertensive rats (SHR) on the development of hypertension in adult life. In a separate study, the role of vasopressin in the maintenance of blood pressure in adult SHR was assessed. Young SHR received either the nonpeptide vasopressin V1A receptor antagonist OPC-21268, the angiotensin-converting enzyme inhibitor ramipril, or vehicle from 6 to 10 weeks of age. During the treatment period, OPC-21268 and ramipril reduced systolic blood pressure compared with control SHR (P < .001). Blood pressure in male SHR 7 weeks after treatment withdrawal was 178 +/- 1 mm Hg in ramipril-treated, 184 +/- 1 mm Hg in OPC-21268-treated, and 200 +/- 2 mm Hg in control SHR (P < .001). Similar results were seen in female SHR, although both OPC-21268 and ramipril were less effective antihypertensive agents in female compared with male SHR. The sustained attenuation in blood pressure was not associated with significant cardiovascular structural changes (left ventricular-to-body weight ratio, renal weight-to-body weight ratio, mesenteric resistance artery media-to-lumen ratio). Results of vasopressin V1A receptor binding kinetics and plasma renin or aldosterone concentrations did not suggest a lasting effect of OPC-21268 on the vasopressin system or of ramipril on the renin-angiotensin system following treatment withdrawal.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.language.isoenen
dc.subject.otherAgingen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.therapeutic useen
dc.subject.otherAnimalsen
dc.subject.otherAntidiuretic Hormone Receptor Antagonistsen
dc.subject.otherBlood Pressureen
dc.subject.otherBody Weighten
dc.subject.otherFemaleen
dc.subject.otherHypertension.genetics.physiopathology.prevention & controlen
dc.subject.otherMaleen
dc.subject.otherPiperidines.therapeutic useen
dc.subject.otherQuinolones.therapeutic useen
dc.subject.otherRamipril.therapeutic useen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.titleAttenuation of genetic hypertension after short-term vasopressin V1A receptor antagonism.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleHypertensionen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages828-34en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7591025en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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