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Title: Autosomal dominant rolandic epilepsy and speech dyspraxia: a new syndrome with anticipation.
Authors: Scheffer, Ingrid E;Jones, L;Pozzebon, M;Howell, R A;Saling, Michael M;Berkovic, Samuel F
Affiliation: Department of Neurology, Austin Hospital, Heidelberg, Melbourne, Australia.
Issue Date: 1-Oct-1995
Citation: Annals of Neurology; 38(4): 633-42
Abstract: We describe a family of 9 affected individuals in three generations with nocturnal oro-facio-brachial partial seizures, secondarily generalized partial seizures, and centro-temporal epileptiform discharges, associated with oral and speech dyspraxia and cognitive impairment. The speech disorder was prominent, but differed from that of Landau-Kleffner syndrome and of epilepsy with continuous spike and wave during slow-wave sleep. The electroclinical features of this new syndrome of autosomal dominant rolandic epilepsy resemble those of benign rolandic epilepsy, a common inherited epilepsy of childhood. This family shows clinical anticipation of the seizure disorder, the oral and speech dyspraxia, and cognitive dysfunction, suggesting that the genetic mechanism could be expansion of an unstable triplet repeat. Molecular studies on this syndrome, where the inheritance pattern is clear, could also be relevant to identifying a gene for benign rolandic epilepsy where anticipation does not occur and the mode of inheritance is uncertain.
Internal ID Number: 7574460
DOI: 10.1002/ana.410380412
Type: Journal Article
Subjects: Adult
Child, Preschool
Epilepsies, Partial.genetics.physiopathology.psychology
Middle Aged
Neuropsychological Tests
Speech Disorders.genetics.physiopathology.psychology
Appears in Collections:Journal articles

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