Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13015
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGoodman, D Jen
dc.contributor.authorClarke, Ben
dc.contributor.authorHope, R Nen
dc.contributor.authorMiach, P Jen
dc.contributor.authorDawborn, J Ken
dc.date.accessioned2015-05-16T02:47:17Z
dc.date.available2015-05-16T02:47:17Z
dc.date.issued1995-05-16en
dc.identifier.citationAmerican Journal of Nephrology; 15(5): 442-5en
dc.identifier.govdoc7503147en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13015en
dc.description.abstractThe aetiology and pathogenesis of focal glomerulosclerosis is poorly understood and many conflicting reports suggest HLA locus associations in both familial and non-familial glomerulosclerosis. We report a family in which 4 of 5 sisters developed proteinuria, 2 with hypertension and 1 progressing to end-stage renal failure (index case). Three underwent renal biopsy which displayed characteristic features of focal glomerulosclerosis and all shared the HLA alleles HLA-A1, B8, DR3, DR7. The index case received two cadaveric renal transplants from HLA-A1, B8, DR3 donors and developed chronic rejection with no histological evidence of recurrent glomerulonephritis in either kidney. The frequency of this haplotype in the Australian dialysis and transplant population with focal glomerulosclerosis was compared to that seen in the general Australian Caucasian population and was not significantly different suggesting that the presence of the HLA alleles HLA-A1, B8, DR3, DR7 may increase the predisposition to familial glomerulosclerosis but additional factors are required for disease development and progression.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAllelesen
dc.subject.otherChromosome Mappingen
dc.subject.otherFamily Healthen
dc.subject.otherFemaleen
dc.subject.otherGenetic Linkageen
dc.subject.otherGlomerulosclerosis, Focal Segmental.genetics.immunologyen
dc.subject.otherHLA Antigens.geneticsen
dc.subject.otherHLA-A1 Antigen.geneticsen
dc.subject.otherHLA-B8 Antigen.geneticsen
dc.subject.otherHLA-DR3 Antigen.geneticsen
dc.subject.otherHLA-DR7 Antigen.geneticsen
dc.subject.otherHumansen
dc.titleFamilial focal glomerulosclerosis: a genetic linkage to the HLA locus?en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican journal of nephrologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.en
dc.description.pages442-5en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/7503147en
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.