Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/13013
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dc.contributor.authorSmyth, Mark Jen
dc.date.accessioned2015-05-16T02:47:09Z
dc.date.available2015-05-16T02:47:09Z
dc.date.issued1995-10-01en
dc.identifier.citationBioessays : News and Reviews in Molecular, Cellular and Developmental Biology; 17(10): 891-8en
dc.identifier.govdoc7487970en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13013en
dc.description.abstractCytotoxic lymphocytes play a central role in immune inflammatory responses against tumour cells, viruses and cells transplanted or infected with intracellular bacteria. The pivotal importance of lymphocytes in each of these immune responses has justified our continued interest in their cytotoxic function. Recent studies of cytotoxic lymphocytes have involved the characterisation of recognition structures on cytotoxic lymphocytes and the definition of two mechanisms of cytotoxicity. In contrast to normal cell death, which occurs during embryonic development and the formation and death of hematopoietic cell lineages, lymphocyte-mediated cytotoxicity occurs in the context of an inflammatory response and the dying cells are lysed into the surroundings rather than phagocytosed. The roles of the two different forms of lymphocyte-mediated cytotoxicity are quite distinct; however they both involve induction of an endogenous pathway of apoptosis in the targeted cell, and they do share features with all other forms of physiological cell death.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCytotoxicity, Immunologicen
dc.subject.otherHumansen
dc.subject.otherImmunityen
dc.subject.otherT-Lymphocytes, Cytotoxic.immunologyen
dc.titleDual mechanisms of lymphocyte-mediated cytotoxicity serve to control and deliver the immune response.en
dc.typeJournal Articleen
dc.identifier.journaltitleBioEssays : news and reviews in molecular, cellular and developmental biologyen
dc.identifier.affiliationCellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia.en
dc.identifier.doi10.1002/bies.950171011en
dc.description.pages891-8en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/7487970en
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