Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13000
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLewis, S Jen
dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorFennessy, M Ren
dc.contributor.authorJarrott, Ben
dc.date.accessioned2015-05-16T02:46:17Z
dc.date.available2015-05-16T02:46:17Z
dc.date.issued1987-08-01en
dc.identifier.citationNeuropharmacology; 26(8): 1167-71en
dc.identifier.govdoc3658120en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13000en
dc.description.abstractThe effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent concentration of histamine in the hypothalamus. These concentrations were 642, 450 and 282 ng/g, respectively. Morphine (10 mg/kg, i.p.) significantly reduced the concentration of histamine in the hypothalamus. Expressed as percentages of the saline-control values (obtained for the extraction volume to tissue weight of 35.7, 57.2 and 118.4 ml/g), treatment with morphine resulted in 24, 17 and 11% reductions in the concentration of histamine in the hypothalamus, respectively. However, expressed in terms of ng/g, the reductions in histamine induced by morphine were 68, 75 and 69 ng/g, respectively. It is concluded that morphine may consistently affect a single pool of histamine. The possibility that de novo histamine is formed in the homogenate during the extraction process is discussed.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherChromatography, Gelen
dc.subject.otherFemaleen
dc.subject.otherHistamine.analysisen
dc.subject.otherHypothalamus.analysis.drug effectsen
dc.subject.otherMorphine.administration & dosage.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherSpectrophotometryen
dc.subject.otherTime Factorsen
dc.titleConcentrations of histamine in the hypothalamus of the rat: effect of extraction volume and interpretation of the effects of acutely-administered morphine.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuropharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1167-71en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3658120en
dc.type.austinJournal Articleen
local.name.researcherVerberne, Anthony J M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

4
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.