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|Title:||Differential effects of surgical sympathectomy on rat heart concentrations of neuropeptide Y-immunoreactivity and noradrenaline.|
|Authors:||Maccarrone, C;Jarrott, B|
|Affiliation:||University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Vic., Australia|
|Citation:||Journal of the Autonomic Nervous System; 21(2-3): 101-7|
|Abstract:||The aim of this study was to estimate the proportion of cardiac neuropeptide Y-immunoreactivity (NPY-ir) which is not present in sympathetic neurones innervating the rat heart. The procedure employed was to surgically sympathectomize the heart and then measure the remaining cardiac concentrations of NPY-ir and noradrenaline (NA). Unilateral (left) sympathectomy significantly reduced the levels of NPY-ir and NA in all regions of the heart (by 40-70%) except for the NPY-ir in the right atrium which was unaltered. The effect of bilateral sympathectomy was significantly greater than that of unilateral sympathectomy. Unilateral and bilateral sympathectomy produced similar reductions in the concentrations of NPY-ir and NA in the ventricular tissue. In contrast dissimilar changes were produced in the atrium. Although bilateral sympathectomy almost totally depleted the NA from the right atrium (by 98%), the NPY-ir levels were only reduced by 50%. These results indicate that approximately half the content of NPY in the right atrium is not present in sympathetic noradrenergic neurones. This pool may occur in the previously described intrinsic neurones of the right atrium.|
|Internal ID Number:||3450689|
Chromatography, High Pressure Liquid
Heart Conduction System.metabolism
Rats, Inbred Strains
Sympathetic Nervous System.metabolism
|Appears in Collections:||Journal articles|
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