Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12977
Title: Verapamil in unstable angina pectoris: failure to demonstrate a relationship between efficacy and plasma levels.
Authors: Powell, A C;Elliott, S L;Horowitz, J D
Affiliation: Department of Cardiology, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 16-May-1988
Citation: Therapeutic Drug Monitoring; 10(1): 34-8
Abstract: Verapamil has been shown to be effective in reducing the frequency of episodes of ischemic pain in patients with unstable angina pectoris, and to be more effective than beta-adrenoceptor antagonists in such patients. However, in many patients ischemic symptoms persist despite verapamil therapy. In a group of 33 consecutive patients admitted to the Coronary Care Unit with unstable angina pectoris and treated with verapamil and nitroglycerin, we prospectively tested the hypothesis that plasma concentrations of verapamil were a direct determinant of resolution of ischemic symptoms over the initial 72-h period of admission. During this period, improvement or resolution of symptoms occurred in 23 of the 33 patients. With patients receiving 240 to 320 mg/day of verapamil, plasma verapamil concentrations varied between 8 and 487 ng/ml, rising significantly with increasing duration of therapy. Mean plasma verapamil concentrations were somewhat greater in patients who improved than in those with ongoing or worsening symptoms, but the differences were not statistically significant. Furthermore, no correlation was found between symptomatic status and plasma concentrations of norverapamil, the active metabolite of verapamil. In one patient cardiac failure worsened, possibly attributable to an elevated plasma verapamil concentration (336 ng/ml). We conclude that in this clinical setting there is little place for routine monitoring of plasma verapamil concentrations.
Internal ID Number: 3376179
URI: http://ahro.austin.org.au/austinjspui/handle/1/12977
URL: http://www.ncbi.nlm.nih.gov/pubmed/3376179
Type: Journal Article
Subjects: Adult
Aged
Aged, 80 and over
Angina Pectoris.prevention & control
Angina, Unstable.prevention & control
Female
Humans
Male
Middle Aged
Rest
Verapamil.analogs & derivatives.blood.pharmacokinetics.therapeutic use
Appears in Collections:Journal articles

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