Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12963
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dc.contributor.authorThurlow, P Jen
dc.contributor.authorConnellan, J Men
dc.contributor.authorKenneally, D Aen
dc.date.accessioned2015-05-16T02:43:48Z
dc.date.available2015-05-16T02:43:48Z
dc.date.issued1987-08-15en
dc.identifier.citationThrombosis Research; 47(4): 427-39en
dc.identifier.govdoc3310325en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12963en
dc.description.abstractA murine monoclonal antibody (anti-C2G7), reactive with fibrinogen, was used to analyse the structure and function of the fibrinogen epitope C2G7. Anti-C2G7 was found to be reactive with fibrinogen but not with fibronectin, Factor VIII-von Willebrand Factor (FVIII-vWF), beta-thromboglobulin (beta TG), platelet factor 4 (PF4) nor with a range of normal cells and cell lines. Biochemical and plasmin digestion studies of fibrinogen revealed that C2G7 is present on the carboxy-terminal end of the alpha chain on a fragment with a Mr approximately 30-40 K. Functional studies, on the role of fibrinogen in coagulation and platelet function, demonstrated the importance of C2G7 (or a closely associated region) for thrombin-associated fibrin polymerization and collagen induced fibrinogen binding to platelets.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAntibodies, Monoclonal.diagnostic useen
dc.subject.otherAntibody Specificityen
dc.subject.otherBlood Coagulationen
dc.subject.otherBlood Platelets.metabolism.physiologyen
dc.subject.otherChemical Phenomenaen
dc.subject.otherChemistryen
dc.subject.otherFibrin.biosynthesisen
dc.subject.otherFibrinogen.metabolism.physiologyen
dc.subject.otherHumansen
dc.subject.otherImmunologic Techniquesen
dc.subject.otherMiceen
dc.subject.otherRadioimmunoassayen
dc.subject.otherThrombin.physiologyen
dc.titleRole of A alpha chain of fibrinogen in coagulation and platelet interaction investigated with a monoclonal antibody.en
dc.typeJournal Articleen
dc.identifier.journaltitleThrombosis researchen
dc.identifier.affiliationDepartment of Haematology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages427-39en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/3310325en
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