Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12959
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVerberne, Anthony J Men
dc.contributor.authorLewis, S Jen
dc.contributor.authorJarrott, Ben
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T02:43:32Z
dc.date.available2015-05-16T02:43:32Z
dc.date.issued1988-02-01en
dc.identifier.citationJournal of Hypertension; 6(2): 123-7en
dc.identifier.govdoc3280675en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12959en
dc.description.abstractPrevious investigations have shown that an excitotoxic lesion of the medial prefrontal cortex (MPFC) in normotensive Sprague-Dawley rats results in a reduction in the sensitivity of the baroreceptor heart rate reflex. The aim of this study was to examine the importance of the MPFC in regulation of the heart rate reflex in conscious, unrestrained spontaneously hypertensive rats (SHR). The MPFC was lesioned by bilateral microinfusions of the excitotoxin N-methyl-D-aspartic acid (NMDA). Baroreceptor heart rate reflex testing was performed by measuring reflex heart rate changes in response to blood pressure alterations induced by nitroprusside and phenylephrine with subsequent computerized sigmoidal curve-fitting of the data. Lesion of the MPFC did not significantly alter resting, systolic and diastolic blood pressure, heart rate or baro-reflex parameters (gain, thresholds, range or plateaus). These observations suggest that the putative descending facilitatory influence from the MPFC to brainstem areas, involved in baroreceptor reflex regulation observed in normotensive rats, may be defective in SHR.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAspartic Acid.analogs & derivatives.pharmacologyen
dc.subject.otherCerebral Cortex.drug effects.physiologyen
dc.subject.otherHeart Rateen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherN-Methylaspartateen
dc.subject.otherPressoreceptors.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherReflex.physiologyen
dc.titleMedial prefrontal cortical lesions and baroreceptor heart rate reflex sensitivity in the spontaneously hypertensive rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Hypertensionen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages123-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3280675en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptClinical Pharmacology and Therapeutics-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

2
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.